Bacterial Systems

The ability of an organism to infect the host and spread disease is referred to as virulence. The chemicals known as virulence factors help the bacterium colonise the host at the cellular level. These elements either have a secretory, membrane-related, or cytosolic character. Quick adaptive changes in the bacterium's metabolism, physiology, and morphology are made possible by cytosolic components. The virulence factors that are connected with the membrane help the bacterium adhere to and avoid the host cell. In the bacterial arsenal, secretory factors play a key role in assisting the bacterium in overcoming the host's innate and adaptive immune response. The secretory virulence factors of extracellular infections work in concert to harm the host cells.

We employ computational tools such as Molecular Docking and Molecular Dynamic Simulations to undertake the exploration of bacterial systems. We identify potential virulent sites and protein and screen out potent drug candidates to inhibit the virulence activity of the bacteria.

If you are interested in undertaking a project related to bacterial virulence and dynamics, feel free to contact us and we will get in touch with you as soon as possible. Read through our research work and explore your interests:

[1] "Antibacterial Property of Biologically Synthesised Iron Nanoparticles Against Staphylococcus aureus", ICAMME 2021, Springer Nature